Exemestane is a permanent aromatase inhibitor (AI), this means that once it binds to the aromatase enzyme it will be completely disabled. That is, Aromasin prevents the enzymes that bind to it from rebounding in quantity after its use is discontinued, so it is different from Arimidex or Letrozole. Unlike Aromasin, by using another AI we can temporarily stop the aromatization, but we run the risk of having an estrogenic rebound when we stop taking them. This is why several anabolic steroid customers suffer from gynecomastia (growth of breast tissue in men) after the cycle if they use other AIs. Scientific evidence with breast cancer patients shows that Aromasin decreased estrogen levels by up to 85%.
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